2-Propen-1-one, 1-[4-[2-[(4-chloro-2-hydroxy-5-iodophenyl)aMino]acetyl]-1-piperazinyl]-
K-Ras(G12C) inhibitor 12
CAS: 1469337-95-8
Molecular Formula: C15H17ClIN3O3
2-Propen-1-one, 1-[4-[2-[(4-chloro-2-hydroxy-5-iodophenyl)aMino]acetyl]-1-piperazinyl]- - Names and Identifiers
2-Propen-1-one, 1-[4-[2-[(4-chloro-2-hydroxy-5-iodophenyl)aMino]acetyl]-1-piperazinyl]- - Physico-chemical Properties
| Molecular Formula | C15H17ClIN3O3 |
| Molar Mass | 449.67 |
| Density | 1.736±0.06 g/cm3(Predicted) |
| Boling Point | 680.2±55.0 °C(Predicted) |
| Solubility | DMSO: ≥ 48 mg/mL |
| pKa | 8.60±0.50(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | K-Ras(G12C) inhibitor 12 belongs to a series of small molecules that irreversibly bind to a common tumorigenic mutant K-Ras(G12C) and block the K-Ras(G12C) interaction. Some of them decreased activity and increased apoptosis of G12C-containing cancer cell lines. K-Ras(G12C) inhibitor 12 belongs to a family of small molecules that irreversibly bind to a common tumorigenic mutant K-Ras(G12C) and block K-Ras(G12C) interactions. Some of them decreased activity and increased apoptosis of G12C-containing cancer cell lines. |
2-Propen-1-one, 1-[4-[2-[(4-chloro-2-hydroxy-5-iodophenyl)aMino]acetyl]-1-piperazinyl]- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.224 ml | 11.119 ml | 22.238 ml |
| 5 mM | 0.445 ml | 2.224 ml | 4.448 ml |
| 10 mM | 0.222 ml | 1.112 ml | 2.224 ml |
| 5 mM | 0.044 ml | 0.222 ml | 0.445 ml |
Last Update：2024-01-02 23:10:35
2-Propen-1-one, 1-[4-[2-[(4-chloro-2-hydroxy-5-iodophenyl)aMino]acetyl]-1-piperazinyl]- - Reference Information
| biological activity | K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of carcinogenic K-Ras(G12C). K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of carcinogenic K-Ras(G12C). |
| in vitro study | K-Ras(G12C) inhibitor 12 is a series of small molecules that irreversibly bind to a common tumorigenic mutant K-Ras(G12C) and block K-Ras(G12C) interaction. Some of them decreased activity and increased apoptosis of G12C-containing cancer cell lines. K-Ras(G12C) inhibitor 12 belongs to a series of small molecules, which irreversibly bind to a common tumorigenic mutant K-Ras(G12C) and block K-Ras(G12C) interaction. Some of them decreased activity and increased apoptosis of G12C-containing cancer cell lines. |
| target | TargetValue K-Ras(G12C) () |
| Target | Value |
Last Update：2024-04-09 21:54:55
![2-Propen-1-one, 1-[4-[2-[(4-chloro-2-hydroxy-5-iodophenyl)aMino]acetyl]-1-piperazinyl]-](http://res.chembk.com/assets/images/structure/HY-18707.gif)
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Spot supply
Product Name: K-Ras(G12C) inhibitor 12 Visit Supplier Webpage Request for quotationCAS: 1469337-95-8
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: K-Ras(G12C) inhibitor 12 Visit Supplier Webpage Request for quotationCAS: 1469337-95-8
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: K-Ras(G12C) inhibitor 12 Visit Supplier Webpage Request for quotationCAS: 1469337-95-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: K-Ras(G12C) inhibitor 12 Visit Supplier Webpage Request for quotationCAS: 1469337-95-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
2-Propen-1-one, 1-[4-[2-[(4-chloro-2-hydroxy-5-iodophenyl)aMino]acetyl]-1-piperazinyl]-
Caffeine Impurity F(EP)
(DES-GLY10,D-ARG6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR (SALMON)
GLUTATHIONE-S-TRANSFERASE SCHISTOSOMA JAPONICUM
3-((4-氯-2-甲基苯氧基)甲基)苯甲酸
Phosphorothioic acid, O-[2-methoxy-4-(1-propenyl)phenyl] O,O-dimethyl ester (9CI)
2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE HYDRATE
1-(Chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tfl.methanesulphonate)
(R)-2-((叔丁氧基羰基)氨基)戊酸甲酯
2-Propenamide,3-[(1,1-dimethylethyl)thio]-, (Z)- (9CI)
Caffeine Impurity F(EP)
(DES-GLY10,D-ARG6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR (SALMON)
GLUTATHIONE-S-TRANSFERASE SCHISTOSOMA JAPONICUM
3-((4-氯-2-甲基苯氧基)甲基)苯甲酸
Phosphorothioic acid, O-[2-methoxy-4-(1-propenyl)phenyl] O,O-dimethyl ester (9CI)
2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE HYDRATE
1-(Chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tfl.methanesulphonate)
(R)-2-((叔丁氧基羰基)氨基)戊酸甲酯
2-Propenamide,3-[(1,1-dimethylethyl)thio]-, (Z)- (9CI)